…it is becoming increasingly obvious that there is unlikely to be a silver bullet solution to such a complex disease [like Alzheimer’s …]. What is needed is a much more holistic approach to the whole disease, rather than trying to compartmentalise it neatly within an ‘amyloid hypothesis’, a ‘Tau hypothesis’ or anything else.
Criticism related to the continued large-scale investment in drug development that builds on one specific disease hypothesis. The full article containing the above quote can be found in Chemistry World.
For a recent scientific review that ‘explores the proposition that we are over-reliant on amyloid to define and diagnose AD and that the time has come to face our fears and reject the amyloid cascade hypothesis’, see for example Karl Herrup’s Perspective article in Nature Neuroscience.